The sodium and postassium ion-stimulated adenosine triphoshatase(Na-K-ATPpase) is the .membrane-embedded enzyme responsible for the active transport of sodium and potassium ions through the cell membrane. And this enzyme is an electrogenic Pump, transporing 3Na^(+) for2K^(+), and is specifically inhibited by the cardiac glycoside, ouatain.
Cyclophosphamide to be to used in chemctherapy of neoplastic diease, is generally useful in the treatment of lymphomas, acute lfmphocytic leukemia in children, and tome solid tumors.
This study was attempted to investigate the effects of cyclephorphamide on Na-K-ATPase activity in the red cell ghosts of the rabbits.
The results are summarized as follows.
1. Na-K-ATPase activity was significantly inhibited by cyclophosphamide at dose of 20.0mg/ml.
2. Ginseng water extract was significantly decreased the inhibited degree of Ha-K-ATPase activity by cyclophosphamide.
3. Mg-ATPase had not any effect under the presence of cyclophosphamide with Ginseng extract or not.
From the above results, it suggested that cyclophosphamide inhibited directly Ta-K-ATPase activity and ginseng water extract enhanced the inhibited the enzymatic activity.
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